Biochem/physiol Actions

Primary TargetEstrogen receptor

Cell permeable: yes

General description

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

Packaging

2 mg in Glass bottle

Physical form

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)